Behansar company’s Dibasic Calcium Phosphate Anhydrous (DCPA) is widely used as an excipient and calcium source in dietary supplements and nutritional products. Thanks to its excellent compressibility and flow characteristics, especially in its coarse grade, it is also employed in pharmaceutical tablet formulations. Due to its abrasive nature, DCPA is used in toothpastes and other dentifrice products. Two particle size grades of DCPA are commonly used in pharmaceutical manufacturing: Milled Grade: Suitable for wet granulation or roller compaction & Coarse Grade: Primarily used in dry granulation and direct compression processes.

Synonymous names in official pharmacopoeias can be seen in the figure below:

Physicochemical properties of calcium phosphate dibasic anhydrous

Dicalcium Phosphate Anhydrous is a white, odorless, tasteless powder or crystalline solid With the chemical formula CaHPO₄, it consists of one calcium ion (Ca²⁺) and one hydrogen phosphate ion (HPO₄²⁻). Unlike its hydrated counterpart (DCPD), DCPA lacks water molecules in its crystal structure. This characteristic leads to greater stability, low solubility, and unique physicochemical properties.

Its crystal lattice is typically monoclinic or hexagonal, a structural arrangement that enhances its stability, biocompatibility, and utility as a functional excipient in solid dosage forms. These characteristics make DCPA a critical ingredient in the development of nutritional and pharmaceutical solid formulations.

Safety and Storage

DCPA is non-hygroscopic and relatively stable under standard storage conditions. It does not convert to the dihydrate form under high humidity. It should be stored in tightly sealed containers in a dry environment to maintain stability.

Incompatibilities

Dicalcium Phosphate Anhydrous should not be used in tetracycline antibiotic formulations. The milled grade also has an alkaline surface pH, making it unsuitable for use with pH-sensitive APIs. However, the coarse grade exhibits an acidic surface pH, which may be compatible in different formulations.

Production of Dibasic Calcium Phosphate Anhydrous at Behansar Company

Behansar Co., as a leading manufacturer of Dibasic Calcium Phosphate Dihydrate, operates advanced GMP-certified production lines and offers reliable and continuous supply for pharmaceutical industries. Behansar supports its clients By Offering technical consultation in excipient selection, as well as providing comprehensive documentation and analytical data in order to Backing research and development processes in both pharmaceutical and nutraceutical sectors. the company is also committed to forming sustainable, long-term partnerships with manufacturers of medicines and dietary supplements, supporting innovation and quality in healthcare.

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